BANGKOK (AP) ? Crude prices vacillated between gains and losses Wednesday as traders waited for the U.S. Energy Department to release its latest oil supply data.
Benchmark crude for September delivery was down 6 cents to $105.24 at midday Bangkok time in electronic trading on the New York Mercantile Exchange. The contract fell $1.26, or 1.2 percent, to close at $105.30 on Tuesday.
Traders were waiting for the U.S. government's Energy Information Agency to release its weekly inventories report later Wednesday. Last week, crude supplies grew 400,000 barrels, or 0.1 percent, to 364.6 million barrels, which is 2.4 percent below year-ago levels.
The International Energy Agency and the Organization of Petroleum Exporting Countries will also release their latest assessments of energy markets, including forecasts for worldwide demand for oil. Analysts are anticipating some downward revisions, given a slowdown in China's economy.
The dollar, however, is underpinning oil prices. It has fallen into a 97-98 yen range, weaker than July when the greenback was worth about 100 yen. A weak dollar tends to boost commodities, which become more attractive investments for holders of other currencies.
"The dollar also not strong enough to suppress the interest in oil so that is why oil prices will hover around the current levels," said Kwong Man Bun, chief operating officer at KGI Securities in Hong Kong.
Brent crude, traded on the ICE Futures exchange in London, was down 37 cents at $107.81 a barrel.
In other energy futures trading on Nymex:
? Heating oil fell 1 cent to $2.998 a gallon.
? Natural gas fell 2 cents to $3.298 per 1,000 cubic feet.
? Wholesale gasoline fell 0.5 cent to $2.91 a gallon.
[unable to retrieve full-text content]Read about How to Get More Website Traffic Post-Penguin 2.0: 4 Free, Easy Things I've Done that's Paying Off. ... I'd go mad if I tried to readjust how I run my online businesses every time Google made an algorithm change. ... If there's one lesson we can all take away from Penguin 2.0, it's that we need to build a community around our content/sites. ... Even before Panda and Penguin, how Google determined the relevancy of any given web page was changing.
Frost & Sullivan recently reported that Apple TV made up more than half of the streaming device market for 2012, beating competitors like Roku and TiVo. Not bad for something that Steve Jobs once referred to as "a hobby" for the company. What should be Apple's next step for the little black box?
First, let's put that news into some context. The Apple TV is the most popular streaming box out there, according to this report - and that's a device that Apple doesn't separately report in its quarterly revenue figures. In fact, the Apple TV's contribution to Apple's balance sheet this past quarter is buried in the "Accessories" portion of its quarterly statement, which for the most recently reported quarter was $1.18 billion (out of $35.23 billion in total revenue).
Compared to the gargantuan revenues of the iPhone ($18.15 billion), the sizable revenues of the iPad ($6.37 billion), or even the Mac ($4.89 billion), that Accessories number is pretty small - especially when you consider that it includes all other Apple-branded hardware peripherals, and accessories made for iPhone, iPad and iPod touch.
But Tim Cook did offer details earlier this year that may give some insight about the success of the Apple TV. In May, Cook said that Apple has sold 13 million Apple TVs to date. About half of those were sold within the previous year, Cook revealed.
That's an average of almost 1.63 million Apple TVs sold each quarter. At $100 a piece, that's $163 million in Apple's coffers from Apple TV each quarter. Some quick back of the envelope math suggests that Apple TV is contributing a little less than 14 percent to Apple's overall "Accessories" revenue numbers. Small potatoes for Apple's balance sheets, perhaps, but if Frost & Sullivan's analysis is correct, a huge chunk of the streaming box market. Apple's biggest competitor, Roku, grabs less than half the remaining pie, according to the report. Other competitors divide what remains into even smaller slivers.
The Apple TV has been around for six years and is already in its third hardware generation. Apple doubling its installed base of Apple TVs in the last twelve months certainly indicates that public momentum for the device is picking up.
But the overall small numbers demonstrate just how nascent the streaming box market really is. While many of us Apple enthusiasts have bought Apple TV, there are still a huge number of consumers who don't find the device particularly useful or interesting, or feel that their TV viewing needs are serviced well enough by cable TV, DVRs and other set-top devices.
Apple's gobbled up a huge piece of a very small pie. But that small market is growing.
Where does Apple go from here?
The second and third generation Apple TV - the small black box - lacks any sort of local storage capability, but makes up for it by being more programmable than its predecessor. Not only is it easily updatable with firmware improvements and other enhancements, but it can be programmed with entirely new apps.
In mid June, Apple rolled out an update for the Apple TV that added support for several new content services including ESPN, HBO, subscription-based anime service Crunchyroll and more.
Some analysts and pundits hope to see the Apple TV become a disruptive technology for television watching - something that people could use in place of cable television altogether. And indeed, some Apple TV users find the content from iTunes, Netflix, Hulu and the other services the Apple TV supports to be sufficient for their viewing habits.
But it's clear that Apple is taking a more iterative approach with the device - an approach that requires customers to have other media at their disposal. Take HBO Go, for example. The app works the same way on the Apple TV that it does on the iPhone and iPad - you can stream HBO content, including current and archived TV series, but it requires you to validate by entering your cable service provider account information first. You can't subscribe to the service a la carte, as it were.
Tim Cook describes a "grand vision" for the Apple TV and calls television itself an "area of intense interest" for the company, but so far he hasn't publicly articulated what that vision is.
According to Frost & Sullivan, the secret to the Apple TV's success is AirPlay, which enables iOS devices and Macs to stream audio and video content to the Apple TV. AirPlay is the killer app for the Apple TV, because it enhances the experience of users of other Apple products by making it easier for them to share content on their television.
Apple implicitly understands this - the company's executives have spoken for years about the "halo effect" of people buying one Apple product and having a great experience with it, then that driving their purchase of more Apple hardware. To that end, AirPlay is getting a big boost in OS X Mavericks, due out later this year. Apple TV owners can already mirror the Mac's display to their television. But with Mavericks' improved Multiple Display support, Mac users will be able to use an Apple TV-connected television as a completely independent display.
The television question
Analysts like Gene Munster have long prognosticated that Apple will build an actual television, but the economics of doing so don't make a lot of sense, at least not right now. Flat panel TVs are an increasingly commodity-drive market, with inexpensive Chinese manufacturers flooding the market with cheap sets you can buy at Walmart and Target.
There may be a window for some new brands to be established in the Ultra HDTV market - the new 4K sets that are coming out. Apple could leverage its legendary supply line muscle with Chinese manufacturers to produce 4K televisions.
And Apple does appear to be making a play for 4K on some of its hardware, like the new Mac Pro, which will feature Thunderbolt 2 interfaces capable of driving 4K resolution displays. But that's a technology that is squarely focused on the high end of Apple's Mac line at the moment, and for the Mac Pro that makes a lot of sense: it's a machine that's historically had a high penetration in the professional digital video and film editing market.
But what, ultimately, would an actual Apple television - 4K or otherwise - gain Apple in the long run? It could establish itself as a niche player - a high end boutique brand, perhaps, but could it muscle itself onto store shelves the same way that competitors like Samsung, LG and Vizio, or long-time players in the field like Sony and Panasonic, have?
Stay the course
It's a smarter play for Apple to continue to to refine the black box with software updates, then roll out a new generation as it makes sense with new features like UHDTV support as it becomes something more consumers are looking for.
While more and more televisions are coming from the factory with "smart" capabilities like connecting to the Internet and to services like Netflix, many consumers continue to use them as simple dumb terminals for their set top boxes and their streaming devices.
For as long as that's the case, Apple's best strategy for the Apple TV remains building a black box that can connect to any of them, instead of building its own branded television. Compared to a television, the Apple TV is almost an impulse buy, and it capitalizes on the halo effect that continues to drive consumers to new Apple products.
Would you buy an Apple-branded television if they make one? Is the Apple TV a better solution? Or is the whole thing stupid? Tell me what you think in the comments.
It's been a long time coming -- close to a year, but OMG Life's clippable, er, lanyard-able life-logging camera will be available to buy tomorrow. The Autographer launches in the UK (where the company's based) and most major European countries on July 30th, priced at a rather prohibitive £400 (we're still confirming a US dollar price, but a later launch has been promised) and pitching itself as "the world's first intelligent wearable camera." We'd position it as an addition to your smartphone and/or standalone camera -- like Lytro or the incoming Memoto -- for those that have the cash.
There's a curious appeal to it, helped by an attractive design that's predominantly plastic. We spent over three days wondering around, sometimes with it on a leather lanyard (included) around our neck, sometimes clipped to our belt or shirt pocket. For better or worse, it's a truly hands-off camera: there's really no way to frame or even time your captures. The Autographer itself chooses when to take a shot using its five sensors (monitoring changes in color, temperature, magnetometer, motion and acceleration), which means there's a hefty dose of luck involved in how your photos turn out. See whether Lady Luck was shining down on us (the sun certainly wasn't) and check out our sample images below and first impressions after the break.
??Assessment of gene expression of intracellular calcium channels, pumps and exchangers with epidermal growth factor-induced epithelial-mesenchymal transition in a breast cancer cell line
Epithelial-mesenchymal transition (EMT) is a process implicated in cancer metastasis that involves the conversion of epithelial cells to a more mesenchymal and invasive cell phenotype. In breast cancer cells EMT is associated with altered store-operated calcium influx and changes in calcium signalling mediated by activation of cell surface purinergic receptors.
In this study, we investigated whether MDA-MB-468 breast cancer cells induced to undergo EMT exhibit changes in mRNA levels of calcium channels, pumps and exchangers located on intracellular calcium storing organelles, including the Golgi, mitochondria and endoplasmic reticulum (ER).
Methods: Epidermal growth factor (EGF) was used to induce EMT in MDA-MB-468 breast cancer cells. Serum-deprived cells were treated with EGF (50 ng/mL) for 12 h and gene expression was assessed using quantitative RT-PCR.Results and conclusionsThese data reveal no significant alterations in mRNA levels of the Golgi calcium pump secretory pathway calcium ATPases (SPCA1 and SPCA2), or the mitochondrial calcium uniporter (MCU) or Na+/Ca2+ exchanger (NCLX).
However, EGF-induced EMT was associated with significant alterations in mRNA levels of specific ER calcium channels and pumps, including (sarco)-endoplasmic reticulum calcium ATPases (SERCAs), and inositol 1,4,5-trisphosphate receptor (IP3R) and ryanodine receptor (RYR) calcium channel isoforms. The most prominent change in gene expression between the epithelial and mesenchymal-like states was RYR2, which was enriched 45-fold in EGF-treated MDA-MB-468 cells.
These findings indicate that EGF-induced EMT in breast cancer cells may be associated with major alterations in ER calcium homeostasis.
Author: Felicity M DavisMichelle T ParsonagePeter J CabotMarie-Odile ParatErik W ThompsonSarah J Roberts-ThomsonGregory R Monteith Credits/Source: Cancer Cell International 2013, 13:76
Published on: 2013-07-29
Copyright by the authors listed above - made available via BioMedCentral (Open Access). Please make sure to read our disclaimer prior to contacting 7thSpace Interactive. To contact our editors, visit our online helpdesk. If you wish submit your own press release, click here. Social Bookmarking RETWEET This! | Digg this! | Post to del.icio.us | Post to Furl | Add to Netscape | Add to Yahoo! | Rojo
The HTC One Mini is in the house - head to the forums for answers to your burning questions
The One Mini is HTC's upcoming 4.3-inch variant of its flagship device, with a 720p display and familiar industrial design. Last week we got our hands we got our hands on the device for a quick preview, but from today we've got one all to ourselves.
We'll have a full HTC One Mini review posted in the days ahead, but until then you can hit up our Q&A thread on the Android Central forums to ask whatever burning questions you might have about the device. If you're not yet a forum member, registration is free, quick and easy.
After years of struggling to become the first offshore wind farm in the United States, Cape Wind in Massachusetts is still battling to be first. After receiving governmental approval and the first federal leases for offshore wind in 2010, the farm is waiting to be built. Meanwhile, states along the eastern seaboard have been battling to be first, although governmental approvals, leases and financial situations often slow the process.
Cape Wind is looking as though they will be the first utility-scale once operations begin at an unknown date. However, the state of Virginia is looking to claim the title of first to install an offshore wind turbine in general. The Virginia Marine Resources Commission recently approved the building of a single turbine in Chesapeake Bay.
Construction on the turbine is expected to begin in the year 2013, a date which is likely to beat any competing states due to the aforementioned need for approvals, leases and financing. The turbine is slated to be 479 feet tall and will be able to generate five megawatts of energy. The turbine will be connected to shore via a three mile cable which is to be buried under the Chesapeake Bay sea floor. Officials are hopeful that the setup will allow for expansion by the year 2015.
All of the approvals necessary for the project to continue are not yet in place. The Army Corps of Engineers and Coast Guard are still required to the state that turbine will not be a liability. Navigation route interference is the main clearance concern at this time.
Spokesman for the Marine Resources Commission, John M.R. Bull, stated: ?Virginia has made this a very streamlined, very favorable permitting process to get things proposed built. If all goes as planned, this one turbine could be a harbinger for a whole new clean-energy industry in Virginia.?
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VV holds a Bachelor's degree in Biology and Chemistry, with an emphasis on environmental studies. VV is an avid participant in animal rights and environmental protection and is for these reasons among many, a vegan. She lives in C...
[unable to retrieve full-text content]The caregivers at CareGivers Plus are available to talk with you and your family about all of your home care needs. CareGivers Plus is an elder care agency providing quality and affordable home care in Mercer, PA and the ...
From blasting fans to sleeping on rooftop patios, Londoners are doing what they can do beat this heat wave.
For renters in London with no air conditioning, it?s becoming a hot mess and there?s no legal requirement landlords provide air conditioning.
?The only obligation is to provide heat from Sept 1. to June 15, no less than 20 degrees,? said Michael Joudrey of Neighbourhood Legal Services.
It?s nothing new, but tenants are constantly turning to home air conditioners, fans and open windows to find relief.
Erika Faust and her fiance have lived in their apartment in Old South for 31/2 years. They have a portable air conditioner but Faust says it?s not nearly enough to cool the place.
?I do have concerns about how hot the apartment can get. Even with the portable air conditioner going, it can be really warm and stuffy in there. Last summer was just unbearable. On those 40-degree humid days, I felt like I couldn?t breathe,? Faust said.
Stefanie Farrant and her roommate have rented a room in a Platt?s Lane apartment building for more than a year. They recently bought a window air conditioner, but Farrant says she hasn?t seen much of an improvement.
?Honestly, it only makes one of the rooms cold anyway, so we sleep with our doors open and have fans blasting the whole night.?
The health unit recommends landlords provide access to a cooler spot in apartment buildings to help residents cool down.
If you?re feeling over-heated at home, it might be time to get out of the apartment.
?For the apartment buildings, normally if they do not have any cool-off spots, for example, or they are a really old building, we do recommend that residents go to a cooling centre in close proximity to get away for a little while, spend time in a cool place so you can cool yourself down,? said the health unit?s Iqbal Kalsi.
For at least one renting couple, their main concern is for those who may not be able to help themselves.
?My only concern would be for my cat. I do have a couple fans that I keep running to try to keep the apartment at a bearable temperature for her,? said Jeremy Brock, who rents an apartment with his fiance in the northeast.
Lynzee Barnett, his fiance, agreed.
?We?re a young couple, so we manage and get a break when we go to work, but it?s unfair for elderly people who maybe can?t afford to move somewhere with air and never get a break, and it?s unfair to our pets.?
Joudrey, of Neighbourhood Legal Services, acknowledged a lack of regulation and it doesn?t appear regulations to require air conditioners are in the cards.
?I can?t say that it can?t change, but there?s been no discussions that I?m aware of,? Joudrey said.
In the meantime, Londoners like Farrant will do what they can to stay cool.
?I stood in the fridge once for a while; I?m not even kidding.?
melanie.anderson@sunmedia.ca
twitter.com/MelatLfpress
WHAT TO DO
The Middlesex London Health Unit recommends landlords take these actions to decrease the risk of heat-related illness to their residents.
Provide access to a cooler spot for several hours at a time, such as a common room with air-conditioning or a basement area.
Keep windows in hallways slightly open to allow air to circulate.
Use fans to draw cool air at night, but don?t rely on a fan as a primary cooling device during long periods of excessive heat.
Provide heat safety information to residents or post the information in common areas.
Have building staff check on at-risk residents every few hours.
Advise residents to drink lots of water and natural fruit juices even if they don?t feel thirsty.
Ask residents to keep windows open and the drapes drawn.
Keep lights off. Do not use stove or oven.
Suggest residents cool down with cool baths, showers, foot baths or by placing cool, wet towels on their necks or underarms.
WHAT TENANTS SAID
?Air conditioners are expensive. The landlord is already paying for utilities. I could only imagine that if everybody in this building has an air conditioner then it would be ridiculously expensive, so having central air would probably save them money.?
? Stefanie Farrant, Platt?s Lane tenant
?In newer buildings, I think AC should be a requirement. In a city that gets as hot and as humid as London does, you need AC just to be able to be somewhat comfortable during this muggy time of year.?
? Erika Faust, Grand Ave. tenant
COOLING CENTRES
For a list of London?s current cooling centres: tinyurl.com/coolingcentres
KANSAS CITY, Mo. (AP) -- Three Missouri groups are getting a total of $1.6 million in federal funds to clean up polluted sites.
The Environmental Protection Agency said in a release Monday that agencies in Jefferson City, St. Louis, and Springfield, will receive a total of $1.6 million in supplemental revolving loan funds to help clean up and redevelop polluted sites.
The Environmental Improvement and Energy Resources Authority in Jefferson City, and the St. Louis Development Corporation will each receive $300,000 to address hazardous substances and $200,000 to address petroleum contamination. The City of Springfield will receive $250,000 to address hazardous substances and $350,000 to cleanup petroleum.
EPA's Brownfields Program targets abandoned and contaminated sites to encourage redevelopment.
Who?s the new hottie you saw on Sunday Night football this past NFL season. That fresh face is NBC Sports Carolyn Manno, who recently joined the network and covered the Olympics. In addition to Football Night in America, she currently works for Comcast Sports Net Boston. She also covered the aircraft carrier college basketball game between Ohio State and Florida.
Carolyn Manno joined the NBCUniversal family in August of 2009 and will be making her Olympic debut at the 2012 Olympic Games?in London as a sports desk anchor and reporter. She currently works as an anchor/reporter for Comcast SportsNet New England and as a contributor to csnne.com. While in Boston, Carolyn covered Super Bowl, Stanley Cup and NBA Finals appearances by the New England Patriots, Boston Bruins and Celtics, in addition to the most epic collapse in Red Sox history in September 2011.
You can follow her on Twitter here
Undisputed fruit roll-up eating champion of 1992. Sneaker and kindness enthusiast.
New York, NY ? http://www.nbcsports.com
She cut her teeth doing hockey, football, and basketball reporting in Boston, and her non-NFL gigs have included MLS and whatever you would call professional skateboarding. As part of her new agreement, Manno serves as a reporter on NBC?s acclaimed NFL studio show, Football Night in America, as well as on NBC and NBC Sports Group coverage of college football and basketball. Additionally, she will be a host on NBC Sports Group?s MLS coverage, and SportsDesk updates, and will serve as a correspondent for NBC Sports Group?s action sports coverage, including the Dew Tour. Manno will also have a role in the new NBC Sports Radio Network as well as a role with NBC?s coverage of the 2014 Sochi Olympic Winter Games.
Paul M. Banks is CEO of The Sports Bank.net, an official Google News site generating millions of unique visitors. He?s also a regular contributor to Chicago Now, Chicago Tribune.com, Fox Sports, MSN, Walter Football and Yardbarker
A Fulbright scholar and MBA, Banks has appeared on live radio all over the world; and he?s a member of the Football Writers Association of America, U.S. Basketball Writers Association, and Society of Professional Journalists. The President of the United States follows him on Twitter (@Paul_M_BanksTSB)You should too
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The U.S. Food and Drug Administration (FDA)?has approved a pharmaceutical drug, Gilotrif, from Boehringer Ingelheim for late-stage, non-small cell lung cancer (NSCLC) patients with a specific mutation. The FDA has also approved a companion genetic test to determine which patients would respond to the treatment. Non-small cell lung cancer constitutes over 85 percent of all lung cancer cases and 10 percent of those have the specific mutation for which this drug is functional.
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"Today's approvals further illustrate how a greater understanding of the underlying molecular pathways of a disease can lead to the development of targeted treatments," said Richard Pazdur, M.D., director of the Office of Hematology and Oncology Products at the FDA's Center for Drug Evaluation and Research, in a press release. "Gilotrif is the second drug approved this year for patients with untreated metastatic NSCLC whose tumors have the EGFR exon 19 deletions or exon 21 L858R substitution mutations."
According to the National Cancer Institute, lung cancer is the leading cause of cancer-related death among Americans. Close to 228,190 Americans are estimated to be diagnosed with lung cancer, and 159,480 will die from the disease this year.
The drug targets growth factor receptors that are present on cancer cells, blocking their function. Gilotrif is also being investigated in a variety of other cancers, such as breast cancer, prostate cancer, head and neck cancers, and gliomas of the brain.
The drug has only been approved as a last-line treatment for those who have experienced failures in previous treatment options. Participants that had received Gilotrif saw a delay in tumor growth (progression-free survival) that was 4.2 months later than those receiving a standard course of chemotherapy. In the clinical trial, there was no statistically significant difference in overall survival.
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Paulina Rubio and Kelly Rowland are "The X Factor's" newest judges.
For the second year in a row, Simon Cowell found himself needing to replace two of the four judges on ?The X Factor.? And when the announcement finally came on Monday that Kelly Rowland and Paulina Rubio would take the spots L.A. Reid and Britney Spears left behind on the panel, the world reacted with a resounding ?Huh??
Neither star brings the buzz that most were expecting from the new hires. Kelly is best known for being in Destiny?s Child, while Paulina is a big name in Latin music and a ?who?s she?? everywhere else. These are really the women that Simon is turning to as he attempts to save ?X Factor? from premature cancellation? The ?Beauties and the Brit? slogan sounds like a great sitcom, but not a reality singing competition.
?Paulina and Kelly both have great taste and massive experience in the music industry and together with Demi, this is going to be a fun panel. It just feels like the time to do something different,? Simon said in the statement announcing the new hires.
?Time to do something different? indeed. ?The X Factor? joined the Fox schedule with high hopes and massive hype two years ago, and to the glee of Simon-haters across the world, that faded quicker than one of his t-shirts after being tossed in the dryer too many times. Since the early days of the American version of the British hit, when he was forced to replace Cheryl Cole and move Nicole Scherzinger from host to judge, nothing has gone right in Simon's effort to replicate the success he enjoyed with ?Idol.? It?s tough to see how these new additions will change anything.
Betting against big names On the one hand, you can?t fault Simon for going away from the TMZ crowd. He spent a lot of cash last year on Britney and Demi Lovato, and viewers stayed away. ?American Idol? brought in Mariah Carey, Keith Urban and Nicki Minaj and still saw its ratings drop and the show get duller. So getting big, controversial celebrities isn't always the best idea.
But bringing in prominent names generates attention, and ?X Factor? desperately needs that. Always in the shadow of ?American Idol,? it?s far behind ?The Voice? and less fun than ?America?s Got Talent.? A decade ago people would turn on the TV just to watch Simon insult people, but that?s not true anymore. A five million dollar prize is gargantuan compared to ?Idol,? but no Powerball drawing.
Nor have its winners jumped to the top of the charts. Season one winner Melanie Amaro?s debut album still hasn?t been released. Tate Stevens, who won last season?s competition, hasn?t caught fire either. Without having produced a superstar, and without any prominent or controversial new faces on the panel, there isn?t any obvious reason for people to watch.
Better be good Unless, that is, Kelly and Paulina are both really combative and entertaining as part of a panel. Simon?s placing a big bet that they are.
The two already know what it takes to judge a reality TV show. Kelly was a judge on the UK version of ?X Factor? in 2011, with her top act finishing in third place. Paulina has been a judge on ?La Voz Mexico? -- that country?s version of ?The Voice,? and will also be a coach on ?La Voz Kids.? She, at least, appears ready to fill a role as the fiery contrast to Simon?s Britishness, saying in her statement ?Simon, be careful what you wish for, let's see if you are ready to handle me, empieza la fiesta, amigo!?
That combativeness is what the show is going to need to succeed. If ?X Factor? is just another singing show with panelists saying nothing but nice things about the contestants and only gently teasing each other, there?s nothing to set it apart from the pack. The Kelly-Paulina-Demi trio has a lot of pressure on it to be fighters, both with each other and Simon, to get people talking about the show again. Odds are close to 100% that we?ll see that kind of sniping in the promotional material for the show once those initial commercials start to air.
?The X Factor's? a huge show in the United Kingdom, and American pop music fans can thank it for introducing the world to One Direction and Leona Lewis. But until it produces a singer of notice on the U.S. version of the show, Kelly and Paulina are going to have to provide an unexpected spark if the show hopes to avoid sinking further than the typical contestant?s career.
SAN FRANCISCO/SEATTLE (Reuters) - Microsoft Corp is set to make a splash this week with the eagerly awaited unveiling of its new Xbox game console, eight years after the last version, as it seeks a larger share of the $65 billion a year global computer gaming industry.
But the small device faces some big competition from the PlayStation 4 by Sony Corp and the Wii U by Nintendo Co Ltd in a shifting market.
Gamers are gravitating to online play - suggesting the hey-day of console games are over - while Microsoft wants its sleek new toy to finally cross the bridge to the mainstream and become the family's entertainment center.
"Core gamers are very hungry for a new machine but the difference between 2005 and now is that the stakes are so much higher," said Ryan McCaffrey, executive editor at entertainment website IGN.com, harking back to Microsoft's last Xbox release. "The entire Xbox experiment from Microsoft was for it to be the center piece of your living room."
To that end, industry-watchers are expecting a raft of improvements from the new Xbox, when Microsoft unveils it at its Redmond, Washington, headquarters on Tuesday, from closer integration with the TV and link-ups with mobile devices to access to new and even exclusive content.
Console gaming still takes the lion's share of a growing gaming market - about 42 percent of the $65 billion world market, according to Microsoft. But playing games on smartphones and tablets, or as an offshoot to online social networks, is gaining ground fast.
Console sales have been in decline for the last four years, chiefly because of aging devices, but the first of the new generation of machines has not reignited the sector.
Nintendo's Wii U, launched in November, had sold only 3.45 million units through the end of March, well below the company's initial forecast of 5.5 million. Hopes for Sony's PS4, teased in March, are low key.
"The next wave crest isn't as high as the previous one," said Lewis Ward, research manager at International Data Corp, who calculates that about 250 million Xbox 360, Sony PlayStation 3 and Nintendo Wii units were sold between 2005 and 2012.
"I do think that consoles as a product category have peaked and the next gen devices won't match those totals," he said.
LOW MARGINS
The Xbox itself is not a key financial factor for the world's largest software maker. Its Entertainment & Devices unit is set to break $10 billion in sales for the first time this year, but that's half the sales of its Windows unit, and a lot less profitable, averaging less than 15 percent margin compared to 60 percent or higher for Windows or Office.
The company has more than 46 million members who subscribe to its online gaming and digital entertainment service Xbox Live, but that's still a fraction of the people who pay for its software.
However, the Xbox is still a key weapon in Microsoft's strategic battle with Google Inc, Apple Inc, Amazon.com Inc and others for a central place in consumers' lives.
"This (the new Xbox) is of massive importance to Microsoft. It is a piece of a larger war for the consumer that it is battling. They want to be fully integrated with the consumer whether it's in the living room or mobile," said P.J. McNealy, CEO and founder of Digital World Research. "Arguably the battle against both Apple and Google for dominating a consumer's time share more so than taking on Sony and Nintendo directly."
That means Microsoft will be aiming for many markets at the same time, from the core and casual gamer to the TV watcher and music fan.
To do that, industry watchers expect Microsoft to integrate the new Xbox much more closely to the TV and cable or satellite box, perhaps allowing users to change channel or buy movies with a wave of the hand through its motion-control Kinect sensor. They also expect to hear more about SmartGlass, Microsoft's app that lets you link an Xbox to a tablet or smartphone.
Users can already get Netflix through the Xbox, and Microsoft recently started its own studio to produce exclusive content, meaning the new device is a gateway to much more than games.
"I think they're going to try to have their cake and eat it too - they will try to get casual people for entertainment while keeping the hardcore gamers interested," said McCaffrey at IGN.com. "They want their console on all the time, whether it's a mom watching Amazon video, the son playing a game and the dad watching (Major League Baseball) TV on another app - that's their goal."
(Additional reporting by Edwin Chan; Editing by Lisa Shumaker)
As much as Europe can hope for deeper integration, it doesn't feel that way when citizens get whacked for hefty roaming rates. European digital commissioner Neelie Kroes has got such charges in her sights, telling business leaders that she's planning to push through a single mobile telecoms market before she retires in 2015. Speaking at the European Business Summit, she said she had "no intention to retire until [she'd] knocked down all the barriers to a single market," which was her "major priority" for the rest of her term. Hopefully those on that side of the pond will never again have to fork over $8 per day just to check Vine.
May 20, 2013 ? A new "telerehabilitation" approach lets physical therapists assess patients with low back pain (LBP) over the Internet, with good accuracy compared with face-to-face examinations, reports a study in the May 15 issue of Spine.
Taking advantage of Skype and other widely-used services may make telerehabilitation a more feasible alternative to in-person clinic visits, according to the new research by Prof. Manuel Arroyo-Morales and colleagues of University of Granada, Spain. They believe their results "give preliminary support to the implementation of web-based LBP assessment systems using video recordings that can be evaluated by different therapists."
Can Back Pain Assessments Be Performed Over the Internet?
The researchers designed and evaluated a web-based telerehabilitation system for performing routine clinical assessments of patients with LBP. The telerehabilitation setup operated across a low-bandwidth Internet connection between two personal computers equipped with webcams.
The system included the popular Skype videoconferencing service, allowing the patient and physical therapist could see and talk to each other in real time. The therapist guided the patient in performing specific movements, and captured video clips for analysis using video motion analysis software (Kinovea). The therapist and patient were also able to complete standard back pain questionnaires using the web-based system.
Fifteen patients with chronic LBP underwent two assessments in random order: once face-to-face and once using the telerehabilitation setup. Accuracy was assessed by comparing the results of telerehabilitation assessment with those of in-person assessment.
The results showed good agreement between the two evaluations, supporting the use of telerehabilitation for clinical assessment of LBP. There was good correlation for measures made on video motion analysis, such as spine mobility and back muscle endurance; as well as questionnaire-based assessments such as disability, pain, and health-related quality of life.
Skype and Other Tools Make Telerehabilitation More Feasible
The telerehabilitation setup showed consistent results for the same therapist at different times (intra-rater reliability) as well as for assessment by independent therapists (inter-rater reliability).
There is growing interest in Internet-based systems for assessment of patients with musculoskeletal disorders. Telerehabilitation approaches could be especially valuable for patient in rural or remote areas, who don't have easy access to healthcare providers.
In the past, the use of telerehabilitation was limited by high equipment costs. The new study shows the successful use of telerehabilitation using widely available and familiar technology, including the use of free software such as Skype.
The telerehabilitation system evaluated in the new study may be useful in assessing patients with the very common problem of LBP, showing good agreement with the results of face-to-face assessment. However, there are still some factors limiting more widespread use -- including the need for "potentially unwieldy" security software to protect patient privacy.
Prof. Arroyo-Morales and coauthors also note that many patients who would otherwise have been eligible for the study weren't included because of a lack of familiarity and experience with computers. The researchers call for further studies in larger groups of patients -- focusing on those who don't have easy access to in-person evaluations.
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In this photo copied from the 2010 Sleepy Hollow High School yearbook, high school student Andrea Rubello is shown. Police said Rubello, a junior at Hofstra University in Hempstead, N.Y., was shot and killed Friday, May 17, 2013, during a break-in near the college campus. (AP Photo/Sleepy Hollow High School)
In this photo copied from the 2010 Sleepy Hollow High School yearbook, high school student Andrea Rubello is shown. Police said Rubello, a junior at Hofstra University in Hempstead, N.Y., was shot and killed Friday, May 17, 2013, during a break-in near the college campus. (AP Photo/Sleepy Hollow High School)
This undated photo provided by the Nassau County Police Department shows Dalton Smith of Hempstead, N.Y. On Saturday, May 18, 2013, police identified Smith the alleged home invader involved in the fatal slaying of a New York college student early Friday morning. Police say that Smith, who was currently on parole for robbery in the first degree, was the person attempting to rob the off-campus home where Andrea Rebello was shot and killed. (AP Photo/Nassau County Police Department)
The Tarrytown, N.Y., home of the family of Hofstra University student Andrea Rubello is seen on Friday, May 17, 2013. Police say Rubello was shot and killed Friday, May 17, 2013, during a break-in near the college campus in Uniondale, N.Y. (AP Photo/Jim Fitzgerald)
Hofstra University students gather near the house where another student and an armed intruder were killed during an overnight house break-in next to the campus, Friday, May 17, 2013, in Uniondale, N.Y. (AP Photo/ Louis Lanzano)
Officers continue working the scene at the house, left, where a Hofstra University student and an armed intruder were killed during an overnight break-in next to the campus, Friday, May 17, 2013, in Uniondale, N.Y. (AP Photo/ Louis Lanzano)
NEW YORK (AP) ? The police officer who accidentally killed a Long Island college student along with an armed intruder faced perhaps the most harrowing decision in law enforcement: choosing the split-second moment when the risk is so high that you must pull the trigger.
That's the moment authorities say a Nassau County police officer experienced early Friday morning when a masked man holding 21-year-old Andrea Rebello in a headlock pointed a loaded handgun at him.
"The big question is, how do you know, when someone's pointing a gun at you, whether you should keep talking to them, or shoot?" said Michele Galietta, a professor of psychology at the John Jay College of Criminal Justice who helps train police officers. "That's what makes the job of an officer amazingly difficult."
She spoke Sunday as Hofstra University students honored Rebello, a popular public relations major, by wearing white ribbons at their graduation ceremony.
On Saturday evening, flags on the Hempstead campus were at half-staff and students held a silent outdoor vigil in front of a photo of the young woman. Surrounded by candles and flowers, they sang "Ave Maria."
Rebello's funeral is scheduled for Wednesday in Sleepy Hollow, in Westchester County, north of New York City.
Her life ended in the seconds that forced the veteran police officer to make a fatal decision, but the questions surrounding the student's death are just beginning, along with an internal investigation by the Nassau County Police Department.
The bare facts are simple. Rebello and the intruder, Dalton Smith, died early Friday when the officer fired eight shots, hitting him seven times, with one bullet striking Rebello once in the head, according to county homicide squad Lt. John Azzata.
With a gun pointed at her, Smith "kept saying, 'I'm going to kill her,' and then he pointed the gun at the police officer," according to Azzata.
The officer acted quickly, saying later that he believed his and Rebello's life were in danger, according to authorities.
No doubt, he was acting to try to save lives ? his own and that of the young woman, Galietta said.
"What we're asking the cop to anticipate is, 'What is going on in the suspect's mind at the moment?'" she said. "We're always trying to de-escalate, to contain a situation, but the issue of safety comes in first, and that's the evaluation the officer has to make."
Eugene O'Donnell, a former New York City police officer and professor of law and police studies at John Jay College, said the crucial issue may be whether or not police had deemed it a hostage situation. If so, he said, there are protocols police follow to buy time, slow down, isolate and assess.
But O'Donnell said the officers may have had few options because of "an eyeball to eyeball confrontation between the officer and the offender."
"It may have been too fluid to deteriorate for the officers to do anything else," O'Donnell said. "It underscores that there's no two of these that are exactly alike."
Police tactical manuals are meant to assist officers in making the best decision possible, but in the end, "they're not 100 percent foolproof," Galietta said. "In a situation like that, you can follow procedure, and it doesn't mean it comes out perfectly."
The officer who fired the shots is an eight-year NYPD veteran and has been with Nassau County police for 12 years.
He is now out on sick leave, Azzata said.
Procedurally, the Nassau County district attorney's office would determine whether an officer's use of deadly force was justified. O'Donnell said. A spokesman for the district attorney's office did not respond to a request for comment Saturday night.
There are some rules governing the use of force for New York police officers. A subsection of Article 35 of New York Penal Law prohibits against recklessly endangering innocent people.
___
Associated Press writers Frank Eltman in Mineola, N.Y., and Jake Pearson contributed to this report.
Contact: Aimee Frank newsroom@gastro.org 301-941-2620 Digestive Disease Week
Innovation for healthy outcomes presented at DDW 2013
Orlando, FL (May 18, 2013) The use of a smartphone application significantly improves patients' preparation for a colonoscopy, according to new research presented today at Digestive Disease Week (DDW). The preparation process, which begins days in advance of the procedure, includes dietary restrictions and requires specific bowel preparation medication to be taken at strict intervals. The better the preparation, the easier it is for doctors to see cancer and precancerous polyps in the colon. The study, which was conducted by the gastroenterologists of Arizona Digestive Health in Phoenix, featured the first doctor-designed app of its kind.
"Getting ready for a colonoscopy is difficult. There are a lot of steps," said Nilay Kavathia, MD, a gastroenterology fellow at Phoenix VA, who is one of the application's developers. "For patients, having an interactive, simplified and personalized app on their phone is like having a doctor at their side throughout the process."
In the study comparing the quality of bowel preparation by patients who used the app and those who did not, Dr. Kavathia found that 84 percent of individuals who used the app received a good score on the nine-point Boston Bowel Preparation Scale. By contrast, only 56 percent of those who didn't use the app received a good score. The results, which correspond with health technology trends, show how advances in smartphones are helping physicians achieve better patient outcomes.
To help increase quality bowel preparation, Dr. Kavathia worked with Dr. Paul Berggreen, the president of Arizona Digestive Health, to develop the "Arizona Digestive Health" app. Patients enter the date and time of the procedure and the bowel preparation medication chosen by their physician. Timed alerts then appear on the phone to remind the individual of the next step in bowel preparation. In addition to the alerts, the app offers information explaining the procedure, tips and pictures of preparation quality. It is available for free download.
Dr. Kavathia would like to build upon his findings by studying individual outcomes of patients who use an app to get ready for a colonoscopy. "We know that better prep means a better colonoscopy," he said, "and now we know that this app improves prep. This finding has huge implications for treatment, patient satisfaction and further research in how the use of technology can impact healthy outcomes."
A colonoscopy serves as a screening test for colorectal cancer and allows a doctor to look for polyps, or precancerous growths, in the colon and rectum. When men and women are considered together, colorectal cancer is the second leading cause of cancer-related deaths in the U.S. and the third most common cancer for both sexes. Colonoscopies for average risk patients are recommended beginning at age 50.
The success of a colonoscopy depends greatly on the quality of bowel preparation by the patient. Inadequate preparation can force cancellation of an exam or can result in a compromised exam in which polyps go undetected, an increase in procedure time and more frequent surveillance.
###
Dr. Kavathia will present data from the study "Outcomes of smart phone application assisted bowel preparation for colonoscopy," abstract 143c, on Saturday, May 18, at 2:30 p.m. ET in Room 203AB of the Orange County Convention Center.
Digestive Disease Week (DDW) is the largest international gathering of physicians, researchers and academics in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. Jointly sponsored by the American Association for the Study of Liver Diseases (AASLD), the American Gastroenterological Association (AGA) Institute, the American Society for Gastrointestinal Endoscopy (ASGE) and the Society for Surgery of the Alimentary Tract (SSAT), DDW takes place May 18 to 21, 2013, at the Orange County Convention Center, Orlando, FL. The meeting showcases more than 5,000 abstracts and hundreds of lectures on the latest advances in GI research, medicine and technology. More information can be found at http://www.ddw.org.
Follow us on Twitter @DDWMeeting; hashtag #DDW13. Become a fan of DDW on Facebook
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Contact: Aimee Frank newsroom@gastro.org 301-941-2620 Digestive Disease Week
Innovation for healthy outcomes presented at DDW 2013
Orlando, FL (May 18, 2013) The use of a smartphone application significantly improves patients' preparation for a colonoscopy, according to new research presented today at Digestive Disease Week (DDW). The preparation process, which begins days in advance of the procedure, includes dietary restrictions and requires specific bowel preparation medication to be taken at strict intervals. The better the preparation, the easier it is for doctors to see cancer and precancerous polyps in the colon. The study, which was conducted by the gastroenterologists of Arizona Digestive Health in Phoenix, featured the first doctor-designed app of its kind.
"Getting ready for a colonoscopy is difficult. There are a lot of steps," said Nilay Kavathia, MD, a gastroenterology fellow at Phoenix VA, who is one of the application's developers. "For patients, having an interactive, simplified and personalized app on their phone is like having a doctor at their side throughout the process."
In the study comparing the quality of bowel preparation by patients who used the app and those who did not, Dr. Kavathia found that 84 percent of individuals who used the app received a good score on the nine-point Boston Bowel Preparation Scale. By contrast, only 56 percent of those who didn't use the app received a good score. The results, which correspond with health technology trends, show how advances in smartphones are helping physicians achieve better patient outcomes.
To help increase quality bowel preparation, Dr. Kavathia worked with Dr. Paul Berggreen, the president of Arizona Digestive Health, to develop the "Arizona Digestive Health" app. Patients enter the date and time of the procedure and the bowel preparation medication chosen by their physician. Timed alerts then appear on the phone to remind the individual of the next step in bowel preparation. In addition to the alerts, the app offers information explaining the procedure, tips and pictures of preparation quality. It is available for free download.
Dr. Kavathia would like to build upon his findings by studying individual outcomes of patients who use an app to get ready for a colonoscopy. "We know that better prep means a better colonoscopy," he said, "and now we know that this app improves prep. This finding has huge implications for treatment, patient satisfaction and further research in how the use of technology can impact healthy outcomes."
A colonoscopy serves as a screening test for colorectal cancer and allows a doctor to look for polyps, or precancerous growths, in the colon and rectum. When men and women are considered together, colorectal cancer is the second leading cause of cancer-related deaths in the U.S. and the third most common cancer for both sexes. Colonoscopies for average risk patients are recommended beginning at age 50.
The success of a colonoscopy depends greatly on the quality of bowel preparation by the patient. Inadequate preparation can force cancellation of an exam or can result in a compromised exam in which polyps go undetected, an increase in procedure time and more frequent surveillance.
###
Dr. Kavathia will present data from the study "Outcomes of smart phone application assisted bowel preparation for colonoscopy," abstract 143c, on Saturday, May 18, at 2:30 p.m. ET in Room 203AB of the Orange County Convention Center.
Digestive Disease Week (DDW) is the largest international gathering of physicians, researchers and academics in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. Jointly sponsored by the American Association for the Study of Liver Diseases (AASLD), the American Gastroenterological Association (AGA) Institute, the American Society for Gastrointestinal Endoscopy (ASGE) and the Society for Surgery of the Alimentary Tract (SSAT), DDW takes place May 18 to 21, 2013, at the Orange County Convention Center, Orlando, FL. The meeting showcases more than 5,000 abstracts and hundreds of lectures on the latest advances in GI research, medicine and technology. More information can be found at http://www.ddw.org.
Follow us on Twitter @DDWMeeting; hashtag #DDW13. Become a fan of DDW on Facebook
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
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Public release date: 18-May-2013
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